Anti-ATRX

Catalog number: HPA001906_100ul
Brand: Atlas Antibodies
Packing: 100 ul
Other sizes: Other size available
Price: € 452.00
Expected delivery time: 7 days
Quantity:
Staining of human liver shows no po...
Immunohistochemical staining of hum...
Immunohistochemical staining of hum...
Immunohistochemistry analysis in hu...
Western blot analysis in A-549 cell...
Immunofluorescent staining of human...
Immunohistochemical staining of hum...

Product specifications for - Anti-ATRX

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; Western Blot
Species: Human
Host: Rabbit
Target: ATRX
Target description: ATRX, chromatin remodeler
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: The antibodies are delivered in 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative.
Storage instructions: Store at +4-¦C for short term storage. Long time storage is recommended at -20-¦C.
Scientific information: 
Scientific info: Specification: This antibody has been used for staining of 48 normal human tissue samples as well as human cancer samples covering the 20 most common cancer types and up to 12 patients for each cancer type.
Gene ID: 546
Swiss prot ID: P46100
Related products: 
Related products: Corresponding Atlas Antigen: APrEST74299
Additional information: 
Synonyms: HPA001906; alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae); ATP-dependent helicase ATRX; JMS; MRX52; RAD54; RAD54L; transcriptional regulator ATRX; XH2; X-linked helicase II; X-linked nuclear protein; XNP; ZNF-HX
Schwartzentruber J, Korshunov A, Liu XY, Jones DT, Pfaff E, Jacob K, Sturm D, Fontebasso AM, Quang DA, Tönjes M, Hovestadt V, Albrecht S, Kool M, Nantel A, Konermann C, Lindroth A, Jäger N, Rausch T, Ryzhova M, Korbel JO, Hielscher T, Hauser P, Garami M, Klekner A, Bognar L, Ebinger M, Schuhmann MU, Scheurlen W, Pekrun A, Frühwald MC, Roggendorf W, Kramm C, Dürken M, Atkinson J, Lepage P, Montpetit A, Zakrzewska M, Zakrzewski K, Liberski PP, Dong Z, Siegel P, Kulozik AE, Zapatka M, Guha A, Malkin D, Felsberg J, Reifenberger G, von Deimling A, Ichimura K, Collins VP, Witt H, Milde T, Witt O, Zhang C, Castelo-Branco P, Lichter P, Faury D, Tabori U, Plass C, Majewski J, Pfister SM, Jabado N. "Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.". Nature 2012 Jan 29; 482(7384):226-31. Epub 2012 Jan 29. DOI: 10.1038/nature10833. Read more
Lovejoy CA, Li W, Reisenweber S, Thongthip S, Bruno J, de Lange T, De S, Petrini JH, Sung PA, Jasin M, Rosenbluh J, Zwang Y, Weir BA, Hatton C, Ivanova E, Macconaill L, Hanna M, Hahn WC, Lue NF, Reddel RR, Jiao Y, Kinzler K, Vogelstein B, Papadopoulos N, Meeker AK, for the ALT Starr Cancer Consortium. "Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway". PLoS Genet 2012; 8(7):e1002772. Epub 2012 Jul 19. DOI: 10.1371/journal.pgen.1002772. Read more
de Wilde RF, Heaphy CM, Maitra A, Meeker AK, Edil BH, Wolfgang CL, Ellison TA, Schulick RD, Molenaar IQ, Valk GD, Vriens MR, Rinkes IH, Offerhaus GJ, Hruban RH, Matsukuma KE. "Loss of ATRX or DAXX expression and concomitant acquisition of the alternative lengthening of telomeres phenotype are late events in a small subset of MEN-1 syndrome pancreatic neuroendocrine tumors". Mod Pathol 2012 Jul; 25(7):1033-1039. Epub 2012 May 11. DOI: 10.1038/modpathol.2012.53. Read more
Heaphy CM, de Wilde RF, Jiao Y, Klein AP, Edil BH, Shi C, Bettegowda C, Rodriguez FJ, Eberhart CG, Hebbar S, Offerhaus GJ, McLendon R, Rasheed BA, He Y, Yan H, Bigner DD, Oba-Shinjo SM, Marie SK, Riggins GJ, Kinzler KW, Vogelstein B, Hruban RH, Maitra A, Papadopoulos N, Meeker AK. "Altered telomeres in tumors with ATRX and DAXX mutations.". Science 2011 Jul 22; 333(6041):425. Epub 2011 Jun 30. DOI: 10.1126/science.1207313. Read more
Abedalthagafi M, Phillips JJ, Kim GE, Mueller S, Haas-Kogen DA, Marshall RE, Croul SE, Santi MR, Cheng J, Zhou S, Sullivan LM, Martinez-Lage M, Judkins AR, Perry A. "The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas.". Mod Pathol 2013 Nov; 26(11):1425-32. Epub 2013 Jun 14. DOI: 10.1038/modpathol.2013.90. Read more
Cleven AH, Suijker J, Agrogiannis G, Briaire-de Bruijn IH, Frizzell N, Hoekstra AS, Wijers-Koster PM, Cleton-Jansen AM, Bovée JV. "IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas". Clin Sarcoma Res 2017 May 4; 7:8. Epub 2017 May 4. DOI: 10.1186/s13569-017-0074-6. Read more