anti-beta Catenin antibody [EM-22]

Catalog number: ARG62681_100ug
Brand: Arigo Biolaboratories
Packing: 100 ug
Price: € 524.00
Expected delivery time: 7 days
Quantity:
ARG62681 anti-beta Catenin antibody [EM-22] ICC/IF image
Immunofluorescence: HT-29 cells sta...
ARG62681 anti-beta Catenin antibody [EM-22] WB image
Western Blot: A. Murine 3T3 cell ly...

Product specifications for - anti-beta Catenin antibody [EM-22]

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: FACS, ICC/IF, ImmunoPrecipitation, Western Blot
Application note: Flow Cytometry: Immunoprecipitation: Western Blotting: Positive control: HT29 human colon adenocarcinoma cell line, FHC human cell line, DLD1 human colon adenocarcinoma cell line KW1 mouse cell line C57MG mouse cell line, 3T3 mouse fibroblast cell lineImmunocytochemistry: Positive control: HT29 human colon adenocarcinoma cell line The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Species: Hamster, Human, Mouse
Host: Mouse
Target: CTNNB1
Target description: catenin (cadherin-associated protein), beta 1, 88kDa
Clonality: Monoclonal
Conjugation: Unconjugated
Isotype: IgG1
Properties: 
Purity: > 95% (by SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: PBS (pH 7.4) and 15 mM Sodium azide
Storage instructions: For continuous use, store undiluted antibody at 2-8-¦C for up to a week. For long-term storage, aliquot and store at -20-¦C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Scientific information: 
Scientific info: Beta-catenin is a multifunctional protein involved both in cell adhesion and in activation of transcription. Calcium-dependent intercellular adhesion transmembrane glycoprotein E-cadherin interacts by its cytoplasmic domain with reciprocally bound alpha, beta and gamma catenin. Beta-catenin links this complex through alpha-actinin to the cytoskeleton. Functional cadherin-catenin system is important for invasiveness of tumour cells. Beta-catenin level in cytoplasm is controlled by glycogen synthase kinase-3 beta. When activity of this kinase is blocked (e.g. by excessive stimulation of Wnt signaling pathway), hypophosphorylated stable form of beta-catenin accumulates in the cytoplasm, translocates to the nucleus and activates transcription of genes including those that are involved in cell cycle control. As a result, cell division and neoplastic transformation are promoted.
Clone ID: EM-22
Gene ID: 1499
Swiss prot ID: P35222
Additional information: 
Synonyms: Inflammation research; ARG62681; Arigo Biolaboratories; b-cat; beta Catenin; Beta Catenin; CTNNB1; armadillo; MRD19; CTNNB; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa