anti-beta Catenin phospho (Ser33 / 37) antibody

Catalog number: ARG52236_100ul
Brand: Arigo Biolaboratories
Packing: 100 ul
Other sizes: Other size available
Price: € 673.00
Expected delivery time: 7 days
Quantity:
ARG52236 anti-beta Catenin phospho (Ser33/37) antibody WB image
Western Blot: human embryonic kidne...

Product specifications for - anti-beta Catenin phospho (Ser33 / 37) antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot
Application note: Specific for the 83k beta-catenin phosphorylated at Ser33 and Ser37. The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Species: Human, Mouse, Rat, Xenopus
Host: Rabbit
Target: CTNNB1
Target description: catenin (cadherin-associated protein), beta 1, 88kDa
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol
Storage instructions: For continuous use, store undiluted antibody at 2-8-¦C for up to a week. For long-term storage, aliquot and store at -20-¦C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Scientific information: 
Scientific info: beta-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002, Polakis, 2000). The role of beta-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3beta (GSK3beta) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of beta-catenin. Mutations in components of this phosphorylation regulated process that prevent beta-catenin hyperphosphorylation by GSK3beta are strongly associated with cancers (Wang et al., 2003, Polakis, 2000, Liu et al., 2002).
Gene ID: 1499
Swiss prot ID: P35222
Additional information: 
Synonyms: Inflammation research; ARG52236; Arigo Biolaboratories; b-cat; beta Catenin; Beta Catenin; CTNNB1; armadillo; MRD19; CTNNB; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa