anti-beta Catenin phospho (Tyr333) antibody

Catalog number: ARG51844_50ul
Brand: Arigo Biolaboratories
Packing: 50 ul
Other sizes: Other size available
Price: € 382.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-beta Catenin phospho (Tyr333) antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot, IHC-P
Application note: The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Species: Human
Host: Rabbit
Target: CTNNB1
Target description: catenin (cadherin-associated protein), beta 1, 88kDa
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: PBS (without Mg2+ and Ca2+, pH 7.4), 150mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Storage instructions: For continuous use, store undiluted antibody at 2-8-¦C for up to a week. For long-term storage, aliquot and store at -20-¦C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Scientific information: 
Scientific info: Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML.
Gene ID: 1499
Swiss prot ID: P35222
Additional information: 
Synonyms: Inflammation research; ARG51844; b-cat; beta Catenin; Beta Catenin; CTNNB1; armadillo; MRD19; CTNNB; catenin beta-1; catenin (cadherin-associated protein), beta 1, 88kDa