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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-Caspase-1 (p10) (mouse), mAb (Casper-2) (Biotin)
Catalog number:
AG-20B-0044B-C100
Brand:
AdipoGen Life Sciences
Packing:
100 ug
Price:
€ 425.00
Expected delivery time:
7 days
Quantity:
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General
References
Product specifications for - anti-Caspase-1 (p10) (mouse), mAb (Casper-2) (Biotin)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Subcategory:
Other
Application:
Western Blot
Species:
Mouse
Host:
Mouse
Target:
Casp1
Target description:
caspase 1
Clonality:
Monoclonal
Conjugation:
Biotin
Isotype:
IgG2a
Properties:
Purity:
>95% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS containing 0.02% sodium azide.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals. - Monoclonal Antibody. Recognizes endogenous full-length and activated (p10 fragment) mouse caspase-1. Isotype: Mouse IgG2a. Clone: Casper-2. Applications: WB. Liquid. In PBS containing 0.02% sodium azide. Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and IL-18 and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3 responds to a variety of agonists including crystals.
Clone ID:
Casper-2
Gene ID:
12362
Swiss prot ID:
P29452
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-20B-0044B-C100; AdipoGen Life Sciences; CASP-1; caspase-1; ICE; IL-1 beta-converting enzyme; IL-1B converting enzyme; Il1bc; IL-1BC; interleukin-1 beta convertase; interleukin-1 beta-converting enzyme; p45
XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation: M. Yabal, et al.; Cell Rep. 7, 1796 (2014)
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AMP-activated protein kinase suppresses urate crystal-induced inflammation and transduces colchicine effects in macrophages: Y. Wang, et al.; Ann. Rheum. Dis. 75, 286 (2016)
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Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome: C. Guo, et al.; Immunity (epub ahead of print) (2016)
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