anti-Caspase-4 /11 (p20)... | AG-20B-0060B-C100 | AdipoGen - Bio-Connect

Find the product you need

Description
Catalog number
CAS No.
Clone ID

General

Product specifications for - anti-Caspase-4 /11 (p20), mAb (Flamy-1) (Biotin)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Subcategory:	Other
Application:	ImmunoPrecipitation; Western Blot
Host:	Mouse
Target:	Casp4
Target description:	caspase 4, apoptosis-related cysteine peptidase
Clonality:	Monoclonal
Isotype:	IgG2b Kappa

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Form supplied:	Liquid. In PBS containing 0.02% sodium azide.
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Inflammatory caspases (also known as group I caspases) are encoded by three main genes in humans, caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. Caspase-11 is the murine orthologue of human caspase-4 and -5. Murine caspase-11 is a poorly characterized member of the caspase-1 subfamily. Caspase-11-deficient embryonic fibroblasts are resistant to apoptosis induced by ectopic expression of caspase-1, suggesting that caspase-11 is an upstream activator of caspase-1. Unlike caspase-1, the expression of caspase-11 is LPS-inducible and it is reasonable to postulate that other members of the family are regulated at the transcriptional or translational level by extracellular stimuli. Recently caspase-11 has been shown to be required for activation of the Nlrp3 inflammasome upon E. coli, V. cholerae and C. rodentium infection. The upstream activators of caspase-11 are TLR4 and TRIF, that modulate enteropathogen-induced inflammasome activation by promoting caspase-11 expression and activation. Formation of ASC foci (specks), a measure of NLRP3/ASC complex formation, requires caspase-11 but not caspase-1 indicating that caspase-11 acts upstream of the NLRP3/ASC complex. - Monoclonal Antibody. Recognizes endogenous full-length protein and activated (p20) fragment of mouse and human caspase-4/11. Isotype: Mouse IgG2bkappa. Clone: Flamy-1. Applications: IP, WB. Liquid. In PBS containing 0.02% sodium azide. Inflammatory caspases (also known as group I caspases) are encoded by three main genes in humans, caspase-1, caspase-4 and caspase-5 and three main genes in mouse, caspase-1, caspase-11 and caspase-12. Caspase-11 is the murine orthologue of human caspase-4 and -5. Murine caspase-11 is a poorly characterized member of the caspase-1 subfamily. Caspase-11-deficient embryonic fibroblasts are resistant to apoptosis induced by ectopic expression of caspase-1, suggesting that caspase-11 is an upstream activator of caspase-1. Unlike caspase-1, the expression of caspase-11 is LPS-inducible and it is reasonable to postulate that other members of the family are regulated at the transcriptional or translational level by extracellular stimuli. Recently caspase-11 has been shown to be required for activation of the Nlrp3 inflammasome upon E. coli, V. cholerae and C. rodentium infection. The upstream activators of caspase-11 are TLR4 and TRIF, that modulate enteropathogen-induced inflammasome activation by promoting caspase-11 expression and activation. Formation of ASC foci (specks), a measure of NLRP3/ASC complex formation, requires caspase-11 but not caspase-1 indicating that caspase-11 acts upstream of the NLRP3/ASC complex.
Clone ID:	Flamy-1
Gene ID:	12363
Swiss prot ID:	P70343

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous

Additional information:
Synonyms:	AG-20B-0060B-C100; AdipoGen Life Sciences; Casp11; CASP-11; CASP-4; caspase 11, apoptosis-related cysteine peptidase; caspase 11, apoptosis-related cysteine protease; caspase 4, apoptosis-related cysteine protease; Caspase-11; caspase-11 short form splicing; caspase-4; Caspl; ich-3; protease ICH-3