Anti-Dynein Antibody, 74 kDa Intermediate chains, cytoplasmic, clone 74.1

Catalog number: MAB1618
Brand: Merck
Packing: 100 ug
Price: On Request
Expected delivery time: 7 days

Product specifications for - Anti-Dynein Antibody, 74 kDa Intermediate chains, cytoplasmic, clone 74.1

Product group: Antibodies
Category: Primary Antibodies
Application: Immunocytochemistry
Application note: Immunocytochemistry: 1:50-1:100 dilution from a previous lot was used. Reacts with cultured MDCK cells, NRR cells, N1E cells, and PTK-1 cells.Immunoprecipitation: 10 uL of a previous lot per 0.5 gm tissue was used. The monoclonal cleanly immunoprecipitates the entire dynein complex stoichiometrically from TX-100 or NP-40 lysates (including the 530 kD heavy chain, the light intermediate chains and the light chains) from various tissues and cultured cell lines. If detergents such as SDS are used to prepare th
Host: Mouse
Target: DNAH3
Target description: dynein, axonemal, heavy chain 3
Clonality: Monoclonal
  Research Use Only
UNSPSC: 12352203
Storage instructions: Stable for 6 months at 2-8-¦C in undiluted aliquots from date of receipt.
Scientific information: 
Scientific info: Eukaryotic cells rely on actin and microtubule-based protein ""motors"" to generate intracellular movements. These protein ""motors"" contain specialized domains that hydrolyse ATP to produce force and movement along a cytoskeletal polymer (actin in the case of myosin family and microtubules in the case of the kinesin family and dyneins). Dynein has been implicated in cytoplasmic motile funtions, including chromosomal movement, retrograde organelle and axonal transport, the endocytic pathway, and the organization of the Golgi apparatus. In all cell types, dynein has the same basic structures and is composed of two or three distinct heavy chains (~450 kDa), three intermediate chains (70-125 kDa), and at least four light chains (15-25 kDa).
Clone ID: 74,1
Gene ID: 55567
Additional information: 
Synonyms: MAB1618; Merck (Millipore)