anti-FADD (human), mAb (1C4) (Biotin)

Catalog number: AG-20B-0080B-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Price: € 285.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-FADD (human), mAb (1C4) (Biotin)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Subcategory: Other
Application: ELISA; ImmunoPrecipitation; Western Blot
Species: Human
Host: Mouse
Target: FADD
Target description: Fas associated via death domain
Clonality: Monoclonal
Conjugation: Biotin
Isotype: IgG1
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells. - Monoclonal Antibody. Recognizes the C-terminus of human FADD only in its unphosphorylated form. Application: ELISA,IP,WB. Clone: 1C4. Isotype: Mouse IgG1. Liquid. In PBS and 0.02% sodium azide. FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells.
Clone ID: 1C4
Gene ID: 8772
Swiss prot ID: Q13158
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; Fas-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; growth-inhibiting gene 3 protein; Mediator of receptor induced toxicity; mediator of receptor-induced toxicity; MORT1; Protein FADD