anti-FADD (human), mAb (1C4) (Biotin)

AdipoGen Life Sciences

anti-FADD (human), mAb (1C4) (Biotin)

10

Recognizes the C-terminus of human FADD only in its unphosphorylated form.

ImmunoPrecipitation, Western Blot, ELISA

Research Use Only

Monoclonal

1C4

1 mg/ml

Biotin

>95%

Liquid

FADD

Fas associated via death domain

Fas (TNFRSF6)-associated via death domain; FAS-associated death domain protein; Fas-associating death domain-containing protein; Fas-associating protein with death domain; GIG3; growth-inhibiting gene 3 protein; mediator of receptor-induced toxicity; MORT1

Mouse

IgG1

FAS-associated death domain protein

FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells. - Monoclonal Antibody. Recognizes the C-terminus of human FADD only in its unphosphorylated form. Application: ELISA,IP,WB. Clone: 1C4. Isotype: Mouse IgG1. Liquid. In PBS and 0.02% sodium azide. FADD (FAS-associated death domain protein) is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. Procaspase-8 belongs to the family of caspases. Binding of FasL to Fas leads to formation of a receptor complex at the cellular membrane, which was named DISC. The DISC consists of oligomerized receptors, the DD-containing adaptor molecule FADD, procaspase-8, procaspase-10 and c-FLIP. The DISC structure provides a platform for the oligomerization of procaspase-8 that allows two procaspase-8 homodimers to be in the close proximity leading to the initial activation of procaspase-8. FADD is also involved in interferon-mediated antiviral immune response and functions in the positive regulation of interferon signaling. FADD also plays a role in embryonic development and the cell cycle reentry of T cells.

Human

-20°C,2°C to 8°C

12352203