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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-Fas (human), mAb (APO-1-3) (preservative free)
Catalog number:
AG-20B-0062PF-C050
Brand:
AdipoGen Life Sciences
Packing:
50 ug
Other sizes:
Other sizes available
Price:
€ 130.00
Expected delivery time:
7 days
Quantity:
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General
References
Product specifications for - anti-Fas (human), mAb (APO-1-3) (preservative free)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
Flow Cytometry; Functional Assay; ImmunoPrecipitation; Western Blot
Species:
Human
Host:
Mouse
Target:
FAS
Target description:
Fas cell surface death receptor
Clonality:
Monoclonal
Isotype:
IgG3
Properties:
Purity:
>95% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappaB. - Monoclonal Antibody. Recognizes human Fas. Isotype: Mouse IgG3. Clone: APO-1-3. Applications: FACS, FUNC, IP, WB. Liquid. In PBS. Fas (CD95) is a member of the death receptor (DR) family, a subfamily of the tumor necrosis factor receptor superfamily. The formation of the Fas death-inducing signaling complex (DISC) is the initial step of Fas signaling. Activation of procaspase-8 at the DISC leads to the induction of DR-mediated apoptosis. Stimulation of Fas has been also reported to trigger non-apoptotic pathways. It has been shown that membrane-bound FasL is essential for the cytotoxic activity, whereas soluble FasL appears to promote autoimmunity and tumorigenesis via induction of non-apoptotic pathways, in particular NF-kappaB.
Clone ID:
APO-1-3
Gene ID:
355
Swiss prot ID:
P25445
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
ALPS1A; APO-1; Apo-1 antigen; APO-1 cell surface antigen; apoptosis antigen 1; apoptosis signaling receptor FAS; apoptosis-mediating surface antigen FAS; APT1; CD95; CD95 antigen; Fas (TNF receptor superfamily, member 6); Fas AMA; FAS1; FASLG receptor; FASTM; mutant tumor necrosis receptor superfamily member 6; TNF receptor superfamily member 6; TNFRSF6; tumor necrosis factor receptor superfamily member 6; tumor necrosis factor receptor superfamily, member 6
Monoclonal antibody-mediated tumor regression by induction of apoptosis: B.C. Trauth, et al.; Science 245, 301 (1989)
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Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia: K.M. Debatin, et al.; Lancet 335, 497 (1990)
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Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens: J. Dhein, et al.; J. Immunol. 149, 3166 (1992)
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APO-1-induced apoptosis of leukemia cells from patients with adult T-cell leukemia: K.M. Debatin, et al.; Blood 81, 2972 (1993)
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The apoptosis-1/Fas protein in human systemic lupus erythematosus: E. Mysler, et al.; J. Clin. Invest. 93, 1029 (1994)
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Inhibition of apoptosis in T cells expressing human T cell leukemia virus type I Tax: K.F. Copeland, et al.; AIDS Res. Hum. Retroviruses 10, 1259 (1994)
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Activation induces sensitivity toward APO-1 (CD95)-mediated apoptosis in human B cells: P.T. Daniel & P.H. Krammer; J. Immunol. 152, 5624 (1994)
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APO-1 (CD95) mediated apoptosis in human T-ALL engrafted in SCID mice: K.M. Lücking-Famira, et al.; Leukemia 8, 1825 (1994)
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Apoptotic cell death induced by a mouse-human anti-APO-1 chimeric antibody leads to tumor regression: L.R. Coney, et al.; Int. J. Cancer 58, 562 (1994)
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Cell nucleus and DNA fragmentation are not required for apoptosis: K. Schulze-Osthoff, et al.; J. Cell Biol. 127, 15 (1994)
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