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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-IL-1alpha (mouse), mAb (Bamboo-2)
Catalog number:
AG-20B-0058-C100
Brand:
AdipoGen Life Sciences
Packing:
100 ug
Price:
€ 350.00
Expected delivery time:
7 days
Quantity:
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General
Product specifications for - anti-IL-1alpha (mouse), mAb (Bamboo-2)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
ELISA
Host:
Mouse
Target:
Il1a
Target description:
interleukin 1 alpha
Clonality:
Monoclonal
Isotype:
IgG1 Kappa
Properties:
Purity:
>95% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Monoclonal Antibody. Recognizes mouse IL-1alpha. Isotype: Mouse IgG1kappa. Clone: Bamboo-2. Applications: ELISA. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner. - The most prominent members of the interleukin-1 (IL-1) superfamily are IL-1alpha and IL-1beta. They lack a signal peptide and are secreted by an unconventional, endoplasmic reticulum-Golgi-independent mechanism. IL-1alpha was reported to be more widely and constitutively expressed and has intracellular functions, but also acts locally in a membrane-bound form by activating IL-1R1. Additionally, passive release of IL-1alpha upon cell death can trigger a sterile inflammatory response to dying cells. The cleavage of IL-1alpha is not mediated by caspase-1 and is not required for binding to IL-1R1. Recently it has been observed that all activators of the inflammasome NLRP3/NALP3 induce the simultaneous secretion of IL-1alpha and IL-1beta. Although most activators fully rely on the inflammasome for IL-1alpha secretion, some induce the processing and secretion of IL-1alpha in an inflammasome-independent manner.
Clone ID:
Bamboo-2
Gene ID:
16175
Swiss prot ID:
P01582
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-20B-0058-C100; AdipoGen Life Sciences; IL-1 alpha; Il-1a; interleukin-1 alpha