Anti-Integrin alpha3 Antibody

Catalog number: AB1920
Brand: Merck
Packing: 100 ul
Price: On Request
Expected delivery time: 7 days

Product specifications for - Anti-Integrin alpha3 Antibody

Product group: Antibodies
Category: Primary Antibodies
Application: ELISA
Application note: ELISA/RIA: A 1:1,000 dilution of a previous lot was used in Enzyme-linked Immunosorbent Assay/Radioimmunoassay.Immunoprecipitation: 5 uL of a previous lot precipitated alpha3/beta1 from 5 x 106 cells (Sherry, D.M., 2001).Immunohistochemistry/immunofluorescence: 1:500 dilution of a previous lot was used, suggest use on acetone-fixed tissue. Western Blot Analysis:1:500 dilution of a previous lot was used.Optimal working dilutions must be determined by end user.
Host: Rabbit
Target: ITGA3
Target description: integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
Clonality: Polyclonal
  Research Use Only
UNSPSC: 12352203
Storage instructions: Stable for 1 year at -20-¦C from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20-¦C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Scientific information: 
Scientific info: Integrins are a family of dimeric, transmembrane proteins that mediate cell-cell and extracellular matrix adhesion. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. The integrin family is composed of at least 19 alpha and 8 beta subunits that form over twenty different alpha-beta non-covalently bound dimeric combinations on the cell surface. Both of the subunits contribute to the binding of the ligand. The alpha-3 subunit (CD49c) is highly concentrated in epithelial cells where it strongly adheres to Laminin-5 and Laminin-5 induced rapid adhesion can be blocked by antibodies against the alpha-3 integrin subunit. The alpha-3 subunit exists in two different splice variants, denoted as ""A"" and ""B"". The only difference that results from this differential splicing is a total change in the cytoplasmic domain, while the extracellular domain stays the same. Knock-out mice lacking this subunit show prenatal lethality and abnormalities in the kidneys.
Gene ID: 3675
Additional information: 
Synonyms: AB1920; Merck (Millipore)