Anti-Integrin alphaV Antibody, C-terminus, Intracellular

Catalog number: AB1930
Brand: Merck
Packing: 100 ul
Price: On Request
Expected delivery time: 7 days

Product specifications for - Anti-Integrin alphaV Antibody, C-terminus, Intracellular

Product group: Antibodies
Category: Primary Antibodies
Application: ELISA
Application note: ELISA/RIA: A 1:1,000 dilution of a previous lot was used in ELISA/RIA.Immunoprecipitation: 5 uL of a previous lot of this antibody is sufficient to precipitate alphaV/beta1 from 5x106 cells. Immunohistochemistry: 1:1000 dilution from a previous lot was used in immunohistochemistry. (Suggested for use an acetone fixed tissue only.) Western blot: 1:5000. The antibody recognizes a single band at approximately 150 kDa when denatured, but not reduced (Hirsch, 1994). Under reducing conditions this antibody recogn
Host: Rabbit
Target: ITGAV
Target description: integrin, alpha V
Clonality: Polyclonal
  Research Use Only
UNSPSC: 12352203
Storage instructions: Stable for 1 year at -20-¦C in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20-¦C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Scientific information: 
Scientific info: The integrin family of cell adhesion receptors consists of at least 19 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. To date, 16 different alpha-subunits and 8 different beta-subunits have been identified. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. Integrin alphaV is a type I membrane glycoptroein with no I (inserted) domain. The alphaV protein is post-translationally cleaved into a heavy and light chain, which is expressed on the cell surface as a disulfide linked polypeptide.
Gene ID: 3685
Additional information: 
Synonyms: AB1930; Merck (Millipore)