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Anti-Integrin alphaVbeta3 Antibody, clone LM609, Alexa Fluor 488 conjugated

Catalog number: MAB1976X
Brand: Merck
Packing: 100 ug
Price: € 645.00
Expected delivery time: 7 days
Quantity:
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Product specifications for - Anti-Integrin alphaVbeta3 Antibody, clone LM609, Alexa Fluor 488 conjugated

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Flow Cytometry
Application note: Flow Cytometry: 1-3 ug LM609 per 0.5 x 10e6 cells in 100uL (Smith, 1996).Immunoprecipitation: Specifically immunoprecipitates the integrin alphaVbeta3 complex which, when resolved by SDS-PAGE under reducing conditions, results in an approximately 130 kDa band corresponding to the alphaV subunit and a 105 kDa band corresponding to the beta3 subunit (Cheresh, 1987). Immunofluorescence: 5-10 ug/mL for staining of bFGF-treated 6 mm cryosections of chick chorioallantoic membrane fixed with acetone (Brooks, 1994)
Host: Mouse
Target: ITGAV
Target description: integrin, alpha V
Clonality: Monoclonal
Properties: 
  Research Use Only
UNSPSC: 12352203
Storage instructions: Maintain for 1 year at 28-¦C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Scientific information: 
Scientific info: The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Key to these molecular interactions between the integrin receptors and their respective ligands is the recognition of the Arg-Gly-Asp (RGD) sequence, known to be present in the extracellular matrix components fibronectin, vitronectin, collagen, fibrinogen, and von Willebrand factor (Cheresh, 1991). The involvement of integrins in vascular proliferation, adhesion, and wound repair has been well documented. The adhesion receptor, integrin alphaVbeta3, appears to be selectively expressed on growing blood vessels and has been identified as a marker of angiogenic vascular tissue (Brooks, 1994). Due to its involvement in angiogenesis, integrin alphaVbeta3 is one of the most intensely studied of the integrin receptors.
Clone ID: LM609
Gene ID: 3685
Additional information: 
Synonyms: MAB1976X; Merck (Millipore)