Tech support
Shopping Cart
Login
Register
Forgot Password?
Products
Diagnostics
Suppliers
About us
Contact
+31 (0)26 326 4450
Find the product you need
Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-LAG-3 (human), mAb (blocking) (17B4) (preservative free)
Catalog number:
AG-20B-0012PF-C100
Brand:
AdipoGen Life Sciences
Packing:
100 ug
Price:
€ 350.00
Expected delivery time:
7 days
Quantity:
Spin Up
Spin Down
General
References
Product specifications for - anti-LAG-3 (human), mAb (blocking) (17B4) (preservative free)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
Flow Cytometry; ImmunoCytoChemistry; ImmunoHistoChemistry; ImmunoPrecipitation; Neutralisation/Blocking; Western Blot
Species:
Human
Host:
Mouse
Target:
LAG3
Target description:
lymphocyte activating 3
Clonality:
Monoclonal
Isotype:
IgG1
Properties:
Purity:
>95% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4. - Monoclonal Antibody. Recognizes human LAG-3. Isotype: Mouse IgG1. Clone: 17B4. Applications: FACS, FUNC (Blocking), ICC, IHC, IP, WB. Liquid. In PBS. Lymphocyte activation gene 3 (LAG-3; CD223) plays an important role in negatively regulating T cell proliferation, function and homeostasis. It is required for maximal natural and induced regulatory T cell (Treg) function. LAG-3 is closely related to the T cell co-receptor CD4 and binds to MHC class II molecules but with a significantly higher affinity than CD4.
Clone ID:
17B4
Gene ID:
3902
Swiss prot ID:
P18627
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-20B-0012PF-C100; AdipoGen Life Sciences; CD223; lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; Protein FDC
Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens: E. Baixeras, et al.; J. Exp. Med. 176, 327 (1992)
Read more
Cellular expression and tissue distribution of the human LAG-3-encoded protein, an MHC class II ligand: B. Huard, et al.; Immunogenetics 39, 213 (1994)
Read more
Characterization of the major histocompatibility complex class II binding site on LAG-3 protein: B. Huard, et al.; PNAS 94, 5744 (1997)
Read more
CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling: S. Hannier, et al.; J. Immunol. 161, 4058 (1998)
Read more
T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts: C.E. Demeure, et al.; Eur. J. Cancer 37, 1709 (2001)
Read more
Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway: E.D. Carlo, et al.; J. Pathol. 205, 82 (2005)
Read more
The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells: L. Macon-Lemaitre & F. Triebel; Immunology 115, 170 (2005)
Read more
A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors: F. Triebel, et al.; Cancer Lett. 235, 147 (2006)
Read more
Human dendritic cells acquire a semimature phenotype and lymph node homing potential through interaction with CD4+CD25+ regulatory T cells: J. Bayry, et al.; J. Immunol. 178, 4184 (2007)
Read more
Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation: C. Casati, et al.; J. Immunol. 180, 3782 (2008)
Read more
See All