anti-LTbetaR (mouse), mAb (4H8 WH2) (preservative free)

Catalog number: AG-20B-0008PF-C100
Brand: AdipoGen Life Sciences
Packing: 100 ug
Other sizes: Other sizes available
Price: € 255.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-LTbetaR (mouse), mAb (4H8 WH2) (preservative free)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Flow Cytometry; Neutralisation/Blocking
Species: Mouse
Host: Rat
Target: Ltbr
Target description: lymphotoxin B receptor
Clonality: Monoclonal
Isotype: IgG2a
Properties: 
Purity: >95% (SDS-PAGE)
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Form supplied: Liquid. In PBS containing 10% glycerol.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival. - The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Clone ID: 4H8 WH2
Gene ID: 17000
Swiss prot ID: P50284
Safety information: 
MSDS: MSDS
Hazard information: Non-hazardous
Additional information: 
Synonyms: AG-20B-0008PF-C100; AdipoGen Life Sciences; AI256028; Ltar; LT-beta receptor; LTbetaR; lymphotoxin-beta receptor; TNF receptor-related protein; Tnfbr; TNFCR; TNFR2-RP; TNF-R-III; TNFRrp; TNFR-RP; Tnfrsf3; tumor necrosis factor receptor superfamily member 3
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways: E. Dejardin, et al.; Immunity 17, 525 (2002) Read more
Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors: B. Silva-Santos, et al.; Science 307, 925 (2005) Read more
LTbetaR Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen. M.F. Vondenhoff, et al.; J. Immunol. 182, 5439 (2009) Read more