anti-LTbetaR (mouse), mAb (4H8 WH2)

AdipoGen Life Sciences

anti-LTbetaR (mouse), mAb (4H8 WH2)

10

Recognizes mouse LTbetaR.

Flow Cytometry, Neutralisation/Blocking

Research Use Only

Monoclonal

4H8 WH2

1 mg/ml

>95%

Liquid

Ltbr

lymphotoxin B receptor

AI256028; L; Ltar; LTbe; LT-beta receptor; LTbetaR; lymphotoxin-beta receptor; TN; Tnf; TNF-; TNF receptor-related protein; Tnfbr; TNFCR; TNFR; TNFR2-RP; TNF-R-III; TNFRrp; TNFR-RP; Tnfrsf3; tumor necrosis factor receptor superfamily member 3

Rat

IgG2a

Tumor necrosis factor receptor superfamily member 3

Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival. - The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Mouse

-20°C,2°C to 8°C

12352203