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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-LTbetaR (mouse), mAb (4H8 WH2)
Catalog number:
AG-20B-0008-C100
Brand:
AdipoGen Life Sciences
Packing:
100 ug
Price:
€ 255.00
Expected delivery time:
7 days
Quantity:
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General
References
Product specifications for - anti-LTbetaR (mouse), mAb (4H8 WH2)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
Flow Cytometry; Neutralisation/Blocking
Species:
Mouse
Host:
Rat
Target:
Ltbr
Target description:
lymphotoxin B receptor
Clonality:
Monoclonal
Isotype:
IgG2a
Properties:
Purity:
>95% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival. - The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.
Clone ID:
4H8 WH2
Gene ID:
17000
Swiss prot ID:
P50284
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-20B-0008-C100; AdipoGen Life Sciences; AI256028; Ltar; LT-beta receptor; LTbetaR; lymphotoxin-beta receptor; TNF receptor-related protein; Tnfbr; TNFCR; TNFR2-RP; TNF-R-III; TNFRrp; TNFR-RP; Tnfrsf3; tumor necrosis factor receptor superfamily member 3
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways: E. Dejardin, et al.; Immunity 17, 525 (2002)
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Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors: B. Silva-Santos, et al.; Science 307, 925 (2005)
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LTbetaR Signaling Induces Cytokine Expression and Up-Regulates Lymphangiogenic Factors in Lymph Node Anlagen. M.F. Vondenhoff, et al.; J. Immunol. 182, 5439 (2009)
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