anti-MLKL phospho (Ser358) antibody

Catalog number: ARG40184_100ul
Brand: Arigo Biolaboratories
Packing: 100 ul
Price: € 476.00
Expected delivery time: 7 days
Quantity:
Western blot: HT-29 cells untreated...

Product specifications for - anti-MLKL phospho (Ser358) antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Western Blot
Species: Human
Host: Rabbit
Target: MLKL
Target description: mixed lineage kinase domain like pseudokinase
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Controle: HT-29 + TNF alpha + Smac mimetic + z-VAD
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Storage instructions: -20-¦C
Scientific information: 
Scientific info: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Gene ID: 197259
Swiss prot ID: Q8NB16
Additional information: 
Synonyms: Inflammation research; ARG40184; hMLKL; mixed lineage kinase domain-like protein