anti-NAIP1/2/5 (mouse), mAb... | AG-20B-0045-C100 | AdipoGen - Bio-Connect

Find the product you need

Description
Catalog number
CAS No.
Clone ID

General

Product specifications for - anti-NAIP1/2/5 (mouse), mAb (Naipa-1)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	Western Blot
Host:	Mouse
Target:	Naip5
Target description:	NLR family, apoptosis inhibitory protein 5
Clonality:	Monoclonal
Isotype:	IgG2b Kappa

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Form supplied:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Monoclonal Antibody. Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain. Isotype: Mouse IgG2bkappa. Clone: Naipa-1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK. - The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
Clone ID:	Naipa-1
Gene ID:	17951
Swiss prot ID:	Q9R016

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous

Additional information:
Synonyms:	AG-20B-0045-C100; AdipoGen Life Sciences; baculoviral IAP repeat-containing 1e; baculoviral IAP repeat-containing protein 1e; Birc1e; Legionella, susceptiblility 1; Lgn1; Naip-rs3; neuronal apoptosis inhibitory protein 5; neuronal apoptosis inhibitory protein, related sequence 3