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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-NAIP1/2/5 (mouse), mAb (Naipa-1)
Catalog number:
AG-20B-0045-C100
Brand:
AdipoGen Life Sciences
Packing:
100 ug
Price:
€ 395.00
Expected delivery time:
7 days
Quantity:
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General
Product specifications for - anti-NAIP1/2/5 (mouse), mAb (Naipa-1)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
Western Blot
Host:
Mouse
Target:
Naip5
Target description:
NLR family, apoptosis inhibitory protein 5
Clonality:
Monoclonal
Isotype:
IgG2b Kappa
Properties:
Purity:
>95% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Monoclonal Antibody. Recognizes mouse NAIP1, 2 and 5. Not tested on mouse NAIP6 and mouse NAIP7 but should also work due to high homology in the BIR2 domain. Isotype: Mouse IgG2bkappa. Clone: Naipa-1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK. - The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.
Clone ID:
Naipa-1
Gene ID:
17951
Swiss prot ID:
Q9R016
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-20B-0045-C100; AdipoGen Life Sciences; baculoviral IAP repeat-containing 1e; baculoviral IAP repeat-containing protein 1e; Birc1e; Legionella, susceptiblility 1; Lgn1; Naip-rs3; neuronal apoptosis inhibitory protein 5; neuronal apoptosis inhibitory protein, related sequence 3