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Anti-Neurofilament M (145 kDa) Antibody, C-terminus

Catalog number: AB1987
Brand: Merck
Packing: 50 ul
Price: On Request
Expected delivery time: 7 days
Quantity:
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Product specifications for - Anti-Neurofilament M (145 kDa) Antibody, C-terminus

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Immunohistochemistry
Application note: Immunohistochemistry: A 1:200 dilution of a previous lot was used in Immunohistochemistry.Staining is not affected by neurofilament phosphorylation. Optimal Staining With TE Buffer, pH 9.0, Epitope Retrieval: Human CerebellumImmunohistochemistry(paraffin): Optimal working dilutions must be determined by end user.
Host: Rabbit
Target: NEFM
Target description: neurofilament, medium polypeptide
Clonality: Polyclonal
Properties: 
  Research Use Only
UNSPSC: 12352203
Storage instructions: Stable for 1 year at -20-¦C in undiluted aliquots from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20-¦C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Scientific information: 
Scientific info: Neurofilaments are a type of intermediate filament that serve as major elements of the cytoskeleton supporting the axon cytoplasm. They are the most abundant fibrillar components of the axon, being on average 3-10 times more frequent than axonal microtubules. Neurofilaments (10nm in dia.) are built from three intertwined protofibrils which are themselves composed of two tetrameric protofilament complexs of monomeric proteins. The neurofilament triplet proteins (68/70, 160, and 200 kDa) occur in both the central and peripheral nervous system and are usually neuron specific. The 68/70 kDa NF-L protein can self-assemble into a filamentous structure, however the 160 kDa NF-M and 200 kDa NF-H proteins require the presence of the 68/70 kDa NF-L protein to co-assemble. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas and neuroblastomas stain positively for neurofilaments. Although typically restricted to neurons, neurofilaments have been detected in paragangliomas and adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilaments.
Gene ID: 4741
Additional information: 
Synonyms: AB1987; Merck (Millipore)