Mouse NLRP3 is detected in mouse macrophages using the monoclonal antibody to NLRP3 (Cryo-2) (Prod. No. AG-20B-0014). Method: Cell extracts from mouse macrophages (BMDMs) WT +/+ (lane 1), NLRP3+/- (lane 2) or NLRP3 -/- (lane 3), with or without tre
Mouse NLRP3 is detected in mouse macrophages using the monoclonal antibody to NLRP3 (Cryo-2) (Prod. No. AG-20B-0014). Method: Cell extracts from mouse macrophages (BMDMs) WT +/+ (lane 1), NLRP3+/- (lane 2) or NLRP3 -/- (lane 3), with or without tre
anti-NLRP3/NALP3, mAb (Cryo-2)
AG-20B-0014
ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetNlrp3
Overview
- SupplierAdipoGen Life Sciences
- Product Nameanti-NLRP3/NALP3, mAb (Cryo-2)
- Delivery Days Customer10
- Antibody SpecificityRecognizes mouse and human NLRP3/NALP3.
- ApplicationsImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDCryo-2
- Concentration1 mg/ml
- Estimated Purity>95%
- FormulationLiquid
- Gene ID216799
- Target nameNlrp3
- Target descriptionNLR family, pyrin domain containing 3
- Target synonymsAGTAVPRL; AII/AVP; Ci; Cias1; cold autoinflammatory syndrome 1 protein homolog; cry; cryopyrin; FCAS; FCU; mast cell maturation-associated-inducible protein 1; Mmig; Mmig1; MWS; N; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; Pyp; Pypaf1; PYRIN-containing APAF1-like protein 1
- HostMouse
- IsotypeIgG2b
- Protein IDQ8R4B8
- Protein NameNACHT, LRR and PYD domains-containing protein 3
- Scientific DescriptionMonoclonal Antibody. Recognizes mouse and human NLRP3/NALP3. Isotype: Mouse IgG2b. Clone: Cryo-2. Applications: IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA). - The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor family, including NLRP3/NALP3, are critical components of the inflammasome that link danger-signals to caspase-1 activation. Defects in NLRP3 are the cause of familial cold autoinflammatory syndrome type 1 (FCAS1), Muckle-Wells syndrome (MWS) and of chronic infantile neurologic cutaneous and articular syndrome (CINCA).
- ReactivityHuman, Mouse
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203