anti-NLRP6/NALP6 (human), mAb (Clint-1)

AdipoGen Life Sciences

anti-NLRP6/NALP6 (human), mAb (Clint-1)

10

Recognizes human NLRP6.

Western Blot, ImmunoHistoChemistry

Research Use Only

Monoclonal

Clint-1

1 mg/ml

>95%

Liquid

NLRP6

NLR family pyrin domain containing 6

angiotensin II/vasopressin receptor; AVR; CLR11.4; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NALP6; NAVR; NAVR/AVR; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PAN3; PYPAF5; PYRIN-containing APAF1-like protein 5

Mouse

IgG1

NACHT, LRR and PYD domains-containing protein 6

Monoclonal Antibody. Recognizes human NLRP6. Isotype: Mouse IgG1kappa. Clone: Clint-1. Applications: IHC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice. - The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. NLRP6/NALP6 is important for intestinal homeostasis by sensing pathogenic commensal bacteria and activating bactericidal activity of macrophages through secretion of IL-18. NLRP6 suppresses inflammation and carcinogenesis by regulating tissue repair and deletion of NLRP6 gene accelerated colitis-associated tumor growth in mice.

Human

-20°C,2°C to 8°C

12352203