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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
anti-NS5B (HCV), mAb (5B-3B1)
Catalog number:
AG-20B-0002-C100
Brand:
AdipoGen Life Sciences
Packing:
100 ug
Price:
€ 345.00
Expected delivery time:
7 days
Quantity:
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General
References
Product specifications for - anti-NS5B (HCV), mAb (5B-3B1)
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
Western Blot
Host:
Mouse
Clonality:
Monoclonal
Isotype:
IgG2b
Properties:
Purity:
>95% (SDS-PAGE)
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352203
Concentration:
1 mg/ml
Form supplied:
Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Monoclonal Antibody. Recognizes HCV NS5B (epitope mapped to NS5B aa 372-382). It recognizes genotype 1 a and also 1b (albeit with lower affinity). It does not recognize genotype 2a. Isotype: Mouse IgG2b. Clone: 5B-3B1. Applications: WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs. - The NS3 serine protease, in association with NS4A, is responsible for the cleavages of the Hepatitis C virus protease complexes NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS5B is a RNA-dependent RNA polymerase that plays an essential role in the virus replication. Hepatitis C virus protease NS3-NS4A colocalizes with IPS-1/VISA/MAVS/Cardif in the mitochondrial membrane and has been shown to cleave the TLR3 adapter TRIF and Cardif to eliminate the antiviral signaling pathways. NS3-NS4A represents an important target for anti-HCV drugs.
Clone ID:
5B-3B1
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous
Additional information:
Synonyms:
AG-20B-0002-C100; AdipoGen Life Sciences
Functional properties of a monoclonal antibody inhibiting the hepatitis C virus RNA-dependent RNA polymerase: D. Moradpour, et al.; J. Biol. Chem. 277, 593 (2002)
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Hepatitis C virus RNA synthesis in a cell-free system isolated from replicon-containing hepatoma cells: R.W. Hardy, et al.; J. Virol. 77, 2029 (2003)
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Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs: G. Randall, et al.; PNAS 100, 235 (2003)
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Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids: S.B. Kapadia and F.V. Chisari; PNAS 102, 2561 (2005)
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Quantitative analysis of the hepatitis C virus replication complex: D. Quinkert, et al.; J. Virol. 79, 13594 (2005)
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Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3: Y.V. Svitkin, et al.; J. Virol. 79, 6868 (2005)
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