anti-Polyglutamylation Modi... | AG-20B-0020-C100

Product specifications for - anti-Polyglutamylation Modification, mAb (GT335)

Overview:
Product group:	Antibodies
Category:	Primary Antibodies
Application:	Electron Microscopy; ImmunoCytoChemistry; ImmunoHistoChemistry; ImmunoPrecipitation; Western Blot
Host:	Mouse
Clonality:	Monoclonal
Isotype:	IgG1 Kappa

Properties:
Purity:	>95% (SDS-PAGE)
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352203
Concentration:	1 mg/ml
Form supplied:	Liquid. In PBS containing 10% glycerol and 0.02% sodium azide.
Storage instructions:	2-¦C to 8-¦C, -20-¦C

Scientific information:
Scientific info:	Monoclonal Antibody. Recognizes the posttranslational modification (poly)glutamylation on proteins. Reacts with polyglutamylated alpha- and beta-tubulin. Isotype: Mouse IgG1kappa. Clone: GT335. Applications: EM, ICC, IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation. - Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation.
Clone ID:	GT335

Scientific information:

Scientific info:

Monoclonal Antibody. Recognizes the posttranslational modification (poly)glutamylation on proteins. Reacts with polyglutamylated alpha- and beta-tubulin. Isotype: Mouse IgG1kappa. Clone: GT335. Applications: EM, ICC, IHC, IP, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation. - Polyglutamylation is a post-translational modification in which glutamate side chains of variable lengths are formed on the modified protein. It is evolutionarily conserved and the most prominent substrate is tubulin, the microtubule (MT) building block. Polyglutamylation has been proposed to be involved in the functional adaptation of MTs, as it occurs within the carboxy-terminal tubulin tails that participate directly in the binding of many structural and motor MT-associated proteins. The recent identification of new substrates of polyglutamylation indicates that this post-translational modification could be a potential regulator of diverse cellular processes and be involved in cell cycle and cell proliferation.

Clone ID:

GT335

Safety information:
MSDS:	MSDS
Hazard information:	Non-hazardous

Additional information:
Synonyms:	AG-20B-0020-C100; AdipoGen Life Sciences

Distribution of glutamylated alpha and beta-tubulin in mouse tissues using a specific monoclonal antibody, GT335: A. Wolff, et al.; Eur. J. Cell Biol. 59, 425 (1992)

Polyglutamylation of nucleosome assembly proteins: C. Regnard, et al.; J. Biol. Chem. 275, 15969 (2000)

Glutamylated tubulin: diversity of expression and distribution of isoforms: M.L. Kann, et al.; Cell Motil. Cytoskeleton 55, 14 (2003)

Polyglutamylation Is a Post-translational Modification with a Broad Range of Substrates: J. van Dijk, et al.; J. Biol. Chem. 283, 3915 (2008)

Tubulin detyrosination promotes monolayer formation and apical trafficking in epithelial cells: S. Zink, et al.; J. Cell Sci. 125, 5998 (2012)

The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly: T. Kobayashi, et al.; J. Cell Biol. 204, 215 (2014)

CNS axons globally increase axonal transport after peripheral conditioning: F.M. Mar, et al.; J. Neurosci. 34, 5965 (2014)

Microtubule detyrosination guides chromosomes during mitosis: M. Barisic, et al.; Science 348, 6236 (2015) (Supplement)

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture: M. Hilbert, et al.; Nat. Cell Biol. 18, 393 (2016)

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anti-Polyglutamylation Modification, mAb (GT335)

Product specifications for - anti-Polyglutamylation Modification, mAb (GT335)

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anti-Polyglutamylation Modification, mAb (GT335)

Product specifications for - anti-Polyglutamylation Modification, mAb (GT335)