anti-SOS1, mAb (AF3F11)

Catalog number: YIF-LF-MA0318
Brand: AbFrontier
Packing: 100 ul
Price: € 309.00
Expected delivery time: 7 days
Quantity:

Product specifications for - anti-SOS1, mAb (AF3F11)

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ELISA; Western Blot
Species: Human, Mouse, Rat
Host: Mouse
Clonality: Monoclonal
Isotype: IgG1 Kappa
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Form supplied: Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol.
Storage instructions: 2-¦C to 8-¦C, -20-¦C
Scientific information: 
Scientific info: Monoclonal Antibody. Recognizes the Human, Mouse, Rat protein. Liquid. HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol. Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex. Promotes the exchange of Ras-bound GDP by GTP. - Son of sevenless (SOS) is a guanine nucleotide exchange factor that activates Ras in response to growth factor stimulation. Sos1, and its closely related Sos2 paralog, are comprised of an N-terminal histone-binding domain, a RacGEF catalytic (DH) domain juxtaposed with a PH domain, a Ras exchanger motif (REM) domain, a RasGEF catalytic domain, and a C-terminal proline-rich region. Sos1 catalyzes the GDP-GTP exchange within the membrane-bound GTPase Ras and thereby switches on a key signaling circuit that involves the activation of MAPK cascade central to cellular proliferation, survival and differentiation. Growth factor stimulation rapidly induces the phosphorylation of Sos on multiple serine and threonine sites. Phosphorylation of residues within the Sos C-terminus by the MAP/ERK kinase disrupts the Grb2-Sos complex. Promotes the exchange of Ras-bound GDP by GTP.
Clone ID: AF3F11
Safety information: 
Hazard information: Non-hazardous
Additional information: 
Synonyms: YIF-LF-MA0318; AbFrontier