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ATR antibody [2B5] - Orthogonal Validated

Catalog number: GTX70109100
Brand: GeneTex
Packing: 100 ul
Price: € 490.00
Expected delivery time: 10 days
Quantity:
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GTX70109 WB Image
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GTX70109 ICC/IF Image
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Product specifications for - ATR antibody [2B5] - Orthogonal Validated

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Functional Assay; ImmunoCytoChemistry; ImmunoFluorescence; ImmunoPrecipitation; Western Blot
Host: Mouse
Target: ATR
Target description: ATR serine/threonine kinase
Clonality: Monoclonal
Isotype: IgG1
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 1 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: Ataxia Telangiectasia Mutated (ATM) and Rad3-related (ATR) protein is a member of the phosphatidyl-inositol 3-kinase (PI 3-kinase) like family of protein kinases. ATR has a predicted molecular mass of approximately 301 kDa, and it has been shown to be involved in cellular responses to DNA damage. Specifically, it plays a role in checkpoint activation in response to either the presence of stalled replication forks, or by the presence of lesions caused by UV light. Inactivation of ATR is an embryonic lethal event in mice.
Clone ID: 2B5
Gene ID: 545
Swiss prot ID: Q13535
Additional information: 
Synonyms: GTX_citation; GTX70109; ataxia telangiectasia and Rad3-related protein; FCTCS; FRAP-related protein 1; FRAP-related protein-1; FRP1; MEC1; MEC1, mitosis entry checkpoint 1, homolog; SCKL; SCKL1; serine/threonine-protein kinase ATR
TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice. Hu L et al., 2018 Mar 15, J Immunol Read more
Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein. Qin B et al., 2013 May 31, J Biol Chem Read more
Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2-C-cyano-2-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Liu X et al., 2008 Jan, Mol Cancer Ther Read more
ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. Zuco V et al., 2010 Jun 28, Cancer Lett Read more
ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Wu X et al., 2007 Feb 1, Oncogene Read more
Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Cui B et al., 2009 Jun, Mol Pharmacol Read more
Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. Katsuki Y et al., 2008 Aug, Cancer Sci Read more
Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress. Furusawa Y et al., 2017 Oct, Apoptosis Read more
Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. Kulkarni A et al., 2008 May, Am J Physiol Lung Cell Mol Physiol Read more
DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. Liu Y et al., 2006 Nov 15, J Cell Sci Read more
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