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GTX70109 ICC/IF Image
GTX70109 ICC/IF Image
GTX70109 ICC/IF Image

ATR antibody [2B5] - Orthogonal Validated

Research Use Only
GTX70109
GeneTex
ApplicationsFunctional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    ATR antibody [2B5] - Orthogonal Validated
  • Delivery Days Customer
    10
  • Applications
    Functional Assay, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2B5
  • Concentration
    1 mg/ml
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • TP53 Haploinsufficiency Rescues Emergency Granulopoiesis in FANCC-/- Mice. Hu L et al., 2018 Mar 15, J Immunol
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  • Ataxia telangiectasia-mutated- and Rad3-related protein regulates the DNA damage-induced G2/M checkpoint through the Aurora A cofactor Bora protein. Qin B et al., 2013 May 31, J Biol Chem
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  • Ataxia-telangiectasia and Rad3-related and DNA-dependent protein kinase cooperate in G2 checkpoint activation by the DNA strand-breaking nucleoside analogue 2-C-cyano-2-deoxy-1-beta-D-arabino-pentofuranosylcytosine. Liu X et al., 2008 Jan, Mol Cancer Ther
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  • ATM- and ATR-mediated response to DNA damage induced by a novel camptothecin, ST1968. Zuco V et al., 2010 Jun 28, Cancer Lett
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  • ATR-dependent checkpoint modulates XPA nuclear import in response to UV irradiation. Wu X et al., 2007 Feb 1, Oncogene
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  • Bifunctional DNA alkylator 1,3-bis(2-chloroethyl)-1-nitrosourea activates the ATR-Chk1 pathway independently of the mismatch repair pathway. Cui B et al., 2009 Jun, Mol Pharmacol
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  • Caffeine yields aneuploidy through asymmetrical cell division caused by misalignment of chromosomes. Katsuki Y et al., 2008 Aug, Cancer Sci
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  • Checkpoint kinase 2 is dispensable for regulation of the p53 response but is required for G2/M arrest and cell survival in cells with p53 defects under heat stress. Furusawa Y et al., 2017 Oct, Apoptosis
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  • Differential roles of ATR and ATM in p53, Chk1, and histone H2AX phosphorylation in response to hyperoxia: ATR-dependent ATM activation. Kulkarni A et al., 2008 May, Am J Physiol Lung Cell Mol Physiol
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  • DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A. Liu Y et al., 2006 Nov 15, J Cell Sci
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