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GTX101310 IHC-P Image
GTX101310 IHC-P Image
GTX101310 IHC-P Image

ATRX antibody [C3], C-term

Research Use Only
GTX101310
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    ATRX antibody [C3], C-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.14 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Docetaxel-loaded solid lipid nanoparticles suppress breast cancer cells growth with reduced myelosuppression toxicity. Yuan Q et al., 2014, Int J Nanomedicine
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  • Functional cross talk between the Fanconi anemia and ATRX/DAXX histone chaperone pathways promotes replication fork recovery. Raghunandan M et al., 2020 May 8, Hum Mol Genet
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  • Is H3K27me3 status really a strong prognostic indicator for pediatric posterior fossa ependymomas? A single surgeon, single center experience. Tanrikulu B et al., 2020 May, Childs Nerv Syst
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  • Paradoxical results obtained with Ki67-labeling and PHH3-mitosis index in glial tumors: a literature analysis. Elmaci I et al., 2017 Nov/Dec, Clin Neuropathol
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