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ProductsBack/Bax antibody [N1N2], N-term
GTX109683 WB Image
GTX109683 WB Image
GTX109683 WB Image

Bax antibody [N1N2], N-term

Research Use Only
GTX109683
GeneTex
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Product group Antibodies
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More than 130 suppliers
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Overview

  • Supplier
    GeneTex
  • Product Name
    Bax antibody [N1N2], N-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1.07 mg/ml
  • Isotype
    IgG
  • Scientific Description
    The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • 15,16-Dihydrotanshinone I from the Functional Food Salvia miltiorrhiza Exhibits Anticancer Activity in Human HL-60 Leukemia Cells: in Vitro and in Vivo Studies. Liu JJ et al., 2015 Aug 17, Int J Mol Sci
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  • A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating alpha-Tubulin Expression. Chang WT et al., 2017 May 21, Molecules
    Read more
  • A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. Rodriguez-Berna G et al., 2014 Aug 18, Eur J Med Chem
    Read more
  • A Tangeretin Derivative Inhibits the Growth of Human Prostate Cancer LNCaP Cells by Epigenetically Restoring p21 Gene Expression and Inhibiting Cancer Stem-like Cell Proliferation. Wei GJ et al., 2019 Jul 10, AAPS J
    Read more
  • Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines. Lee JG et al., 2014 Jun, Toxicol In Vitro
    Read more
  • Acrylamide-induced mitochondria collapse and apoptosis in human astrocytoma cells. Chen JH et al., 2013 Jan, Food Chem Toxicol
    Read more
  • Anti-Interleukin-16-Neutralizing Antibody Attenuates Cardiac Inflammation and Protects against Cardiac Injury in Doxorubicin-Treated Mice. Zhang J et al., 2021, Mediators Inflamm
    Read more
  • Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species. Lee CW et al., 2019 Aug, J Cell Physiol
    Read more
  • Astrakurkurone, a sesquiterpenoid from wild edible mushroom, targets liver cancer cells by modulating Bcl-2 family proteins. Dasgupta A et al., 2019 Jul, IUBMB Life
    Read more
  • Benzyl isothiocyanate (BITC) triggers mitochondria-mediated apoptotic machinery in human cisplatin-resistant oral cancer CAR cells. Lee CF et al., 2018 Sep, Biomedicine (Taipei)
    Read more