GTX70123 WB Image
BRCA2 antibody [5F6]
GTX70123
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
Overview
- SupplierGeneTex
- Product NameBRCA2 antibody [5F6]
- Delivery Days Customer10
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID5F6
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionInherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
- ReactivityHuman
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. Bernard-Gallon DJ et al., 2001, Breast Cancer ResRead more
- Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer? Bosviel R et al., 2012 May, OMICSRead more
- Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. Bernard-Gallon DJ et al., 2004 Jan-Feb, Anticancer ResRead more
- Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses. Soni A et al., 2021 May, DNA Repair (Amst)Read more