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GTX70123 WB Image
GTX70123 WB Image
GTX70123 WB Image

BRCA2 antibody [5F6]

Research Use Only
GTX70123
GeneTex
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    BRCA2 antibody [5F6]
  • Delivery Days Customer
    10
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5F6
  • Concentration
    1 mg/ml
  • Host
    Mouse
  • Isotype
    IgG
  • Scientific Description
    Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. Bernard-Gallon DJ et al., 2001, Breast Cancer Res
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  • Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer? Bosviel R et al., 2012 May, OMICS
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  • Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. Bernard-Gallon DJ et al., 2004 Jan-Feb, Anticancer Res
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  • Proficiency in homologous recombination repair is prerequisite for activation of G2-checkpoint at low radiation doses. Soni A et al., 2021 May, DNA Repair (Amst)
    Read more