GTX103436 ICC/IF Image
GTX103436 ICC/IF Image
c-Myc antibody
GTX103436
Product group Antibodies
Overview
- SupplierGeneTex
- Product Namec-Myc antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.29 mg/ml
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitts lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A Munc18-1 mutant mimicking phosphorylation by Down Syndrome-related kinase Dyrk1a supports normal synaptic transmission and promotes recovery after intense activity. Classen J et al., 2020 Feb 21, Sci RepRead more
- A regulatory loop among CD276, miR-29c-3p, and Myc exists in cancer cells against natural killer cell cytotoxicity. Lee CC et al., 2021 Jul 15, Life SciRead more
- ACSL4 promotes hepatocellular carcinoma progression via c-Myc stability mediated by ERK/FBW7/c-Myc axis. Chen J et al., 2020 Apr 29, OncogenesisRead more
- Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets. Lin HC et al., 2017 Jan 11, J Agric Food ChemRead more
- CD36 inhibits beta-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis. Fang Y et al., 2019 Sep 4, Nat CommunRead more
- Cellular density-dependent increases in HIF-1alpha compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Seira N et al., 2018 Dec, Pharmacol Res PerspectRead more
- ChIP-on-chip analysis of thyroid hormone-regulated genes and their physiological significance. Chung IH et al., 2016 Apr 19, OncotargetRead more
- Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development. Ma YX et al., 2017, Front Mol NeurosciRead more
- Downregulation of Light-Harvesting Complex II Induces ROS-Mediated Defense Against Turnip Mosaic Virus Infection in Nicotiana benthamiana. Qiu S et al., 2021, Front MicrobiolRead more
- FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis. Fu Y et al., 2015 Aug, Med OncolRead more