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Caspase 3 antibody - KO/KD, Orthogonal, IP/MS Validated

Catalog number: GTX110543_100ul
Brand: GeneTex
Packing: 100 ul
Other sizes: Other size available
Price: € 395.00
Expected delivery time: 10 days
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GTX110543 ICC/IF Image
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GTX110543 IHC-P Image
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GTX110543 WB Image
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GTX110543 WB Image
GTX110543 WB Image...
GTX110543 WB Image
GTX110543 WB Image...
GTX110543 WB Image
GTX110543 WB Image...
GTX110543 IHC-P Image
GTX110543 IHC-P Image...
GTX110543 IP Image
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GTX110543 WB Image
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Product specifications for - Caspase 3 antibody - KO/KD, Orthogonal, IP/MS Validated

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Frozen; ImmunoHistoChemistry Parrafin; ImmunoPrecipitation; Western Blot
Species: Human, Mouse, Rat
Host: Rabbit
Target: CASP3
Target description: caspase 3
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Controle: HeLa , HeLa (30 microM Cisplatin treatment for 24 hr) , PC-12 (30uM cisplatin treatment for 24h) , PC-12 , Rat2 , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , Jurkat , Raji , NCI-H929 , K562 , THP-1 , HL-60
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 0.61 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimers disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq]
Gene ID: 836
Swiss prot ID: P42574
Additional information: 
Synonyms: GTX_citation; GTX110543; apopain; CASP-3; caspase 3, apoptosis-related cysteine peptidase; caspase 3, apoptosis-related cysteine protease; caspase-3; CPP32; CPP-32; CPP32B; cysteine protease CPP32; PARP cleavage protease; procaspase3; protein Yama; SCA-1; SREBP cleavage activity 1
4beta-Hydroxywithanolide E Modulates Alternative Splicing of Apoptotic Genes in Human Hepatocellular Carcinoma Huh-7 Cells. Lee CC et al., 2017 Aug 4, Sci Rep Read more
A high-throughput pipeline for validation of antibodies. Sikorski K et al., 2018 Nov, Nat Methods Read more
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An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury. Gupta R et al., 2019 Apr, Free Radic Biol Med Read more
An extract of Rhodobacter sphaeroides reduces cisplatin-induced nephrotoxicity in mice. Chang WW et al., 2013 Nov 29, Toxins (Basel) Read more
Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro. Chin YT et al., 2014 Dec 30, Oncotarget Read more
Apoptosis perturbations and expression of regulatory inflammatory factors in cisplatin-depleted rat livers under l-arginine protection. El-Sayed RM et al., 2019 May, Can J Physiol Pharmacol Read more
Artocarpin induces cell apoptosis in human osteosarcoma cells through endoplasmic reticulum stress and reactive oxygen species. Lee CW et al., 2019 Aug, J Cell Physiol Read more
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