CD146 Antibody / MCAM / MUC18

Biorbyt

CD146 Antibody / MCAM / MUC18

16

ImmunoHistoChemistry

Immunohistochemistry (FFPE): 1-2ug/ml IHC-P

Research Use Only

MCAM/3048

IgG

The human Mel-CAM gene maps to chromosome 11q23 and encodes a trans-membrane glycoprotein, also designated MCAM, MUC 18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human melanomas and correlates well with development of metastatic disease.

12352203