Overview
- SupplierGeneTex
- Product NameCYFIP1 antibody [N1N2], N-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1 mg/ml
- IsotypeIgG
- Scientific DescriptionComponent of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Involved in formation of membrane ruffles and lamellipodia protrusions and in axon outgrowth. Binds to F-actin but not to RNA. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers.
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP. Majumder P et al., 2016 Nov, Acta NeuropatholRead more