ETO / RUNX1T1 antibody - ChIP grade

GeneTex

ETO / RUNX1T1 antibody - ChIP grade

10

ChIP Chromatin ImmunoPrecipitation, ELISA

Research Use Only

Polyclonal

Rabbit

IgG

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5-region of the runt-related transcription factor 1 gene fused to the 3-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

Human

2°C to 8°C,-20°C

12352203