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GTX109679 WB Image
GTX109679 WB Image
GTX109679 WB Image

HDAC3 antibody [C3], C-term

Research Use Only
GTX109679
GeneTex
Product group Antibodies
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    HDAC3 antibody [C3], C-term
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Isotype
    IgG
  • Scientific Description
    Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Exercise increases the binding of MEF2A to the Cpt1b promoter in mouse skeletal muscle. Yuan H et al., 2014 Dec, Acta Physiol (Oxf)
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  • Hydroxygenkwanin Inhibits Class I HDAC Expression and Synergistically Enhances the Antitumor Activity of Sorafenib in Liver Cancer Cells. Chen CY et al., 2020, Front Oncol
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  • Inhibition of HDAC3- and HDAC6-Promoted Survivin Expression Plays an Important Role in SAHA-Induced Autophagy and Viability Reduction in Breast Cancer Cells. Lee JY et al., 2016, Front Pharmacol
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  • NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death. Huang D et al., 2018 Oct, Nat Immunol
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  • NudC deacetylation regulates mitotic progression. Chuang C et al., 2013, PLoS One
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