GTX25654 WB Image
Her2 / ErbB2 (phospho Tyr1248) antibody
GTX25654
ApplicationsWestern Blot
Product group Antibodies
ReactivityCanine, Hamster, Human, Rat
Overview
- SupplierGeneTex
- Product NameHer2 / ErbB2 (phospho Tyr1248) antibody
- Delivery Days Customer10
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.5 mg/ml
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Scientific DescriptionErbB2 (also known as Her2 or neu) is a 185 kDa transmembrane receptor tyrosine kinase from the EGFR family that acts to regulate a variety of biological responses including cell growth, differentiation, and tissue development. Ligand binding to the extracellular domain, or overexpression of the receptor leads to phosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Overexpression or abnormal activation of ErbB2 has been found in a variety of tumors including brain, breast, lung and skin cancer. Tyrosine 1248 within the cytoplasmic domain of the receptor is an auto-phosphorylation site that allows binding of Shc and activation of the Ras, Raf, ERK1&2 signaling pathway.
- ReactivityCanine, Hamster, Human, Rat
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- High cell-surface density of HER2 deforms cell membranes. Chung I et al., 2016 Sep 7, Nat CommunRead more