Overview
- SupplierGeneTex
- Product NameHIF1 alpha antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.48 mg/ml
- IsotypeIgG
- Scientific DescriptionHypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of an alpha subunit and a beta subunit. The beta subunit has been identified as the aryl hydrocarbon receptor nuclear translocator (ARNT). This gene encodes the alpha subunit of HIF-1. Overexpression of a natural antisense transcript (aHIF) of this gene has been shown to be associated with nonpapillary renal carcinomas. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
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- A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition. Kitajima S et al., 2021 Feb 25, Sci RepRead more
- A novel family of fluorescent hypoxia sensors reveal strong heterogeneity in tumor hypoxia at the cellular level. Erapaneedi R et al., 2016 Jan 4, EMBO JRead more
- Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression. Hassan A et al., 2018, PLoS OneRead more
- Acute intermittent hypoxia enhances regeneration of surgically repaired peripheral nerves in a manner akin to electrical stimulation. Nadeau JR et al., 2021 Jul, Exp NeurolRead more
- Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation. Ji Y et al., 2017 May 18, Nat CommunRead more
- Adverse early-life environment impairs postnatal lung development in mice. Lai PY et al., 2019 Sep 1, Physiol GenomicsRead more
- AHNAK2 is a Novel Prognostic Marker and Oncogenic Protein for Clear Cell Renal Cell Carcinoma. Wang M et al., 2017, TheranosticsRead more
- An Adaptation System to Avoid Apoptosis via Autophagy Under Hypoxic Conditions in Pancreatic Cancer Cells. Owada S et al., 2017 Sep, Anticancer ResRead more
- An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress. Nuechel J et al., 2021 Aug 19, Mol CellRead more