GTX60892 WB Image
Histone H3K27me3 (Tri-methyl Lys27) antibody [RM175]
GTX60892
ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
Overview
- SupplierGeneTex
- Product NameHistone H3K27me3 (Tri-methyl Lys27) antibody [RM175]
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, Western Blot, ChIP Chromatin ImmunoPrecipitation, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDRM175
- HostRabbit
- IsotypeIgG
- Modification TypeMethylated
- Scientific DescriptionHistones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments. Wang CY et al., 2019 Jul 3, Nat CommunRead more
- Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1). Sunwoo H et al., 2017 Oct 3, Proc Natl Acad Sci U S ARead more
- SMCHD1 Merges Chromosome Compartments and Assists Formation of Super-Structures on the Inactive X. Wang CY et al., 2018 Jul 12, CellRead more
- Xist Deletional Analysis Reveals an Interdependency between Xist RNA and Polycomb Complexes for Spreading along the Inactive X. Colognori D et al., 2019 Apr 4, Mol CellRead more
- Xist Repeats A and B Account for Two Distinct Phases of X Inactivation Establishment. Colognori D et al., 2020 Jul 6, Dev CellRead more