GTX100519 IHC-P Image
GTX100519 IHC-P Image
HMGA2 antibody - ChIP grade
GTX100519
Product group Antibodies
Overview
- SupplierGeneTex
- Product NameHMGA2 antibody - ChIP grade
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.083 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- An HMGA2-p62-ERalpha axis regulates uterine leiomyomas proliferation. Liu B et al., 2020 Aug, FASEB JRead more
- An Integrated Bioinformatics Analysis Repurposes an Antihelminthic Drug Niclosamide for Treating HMGA2-Overexpressing Human Colorectal Cancer. Leung SW et al., 2019 Oct 2, Cancers (Basel)Read more
- Dicoumarol suppresses HMGA2-mediated oncogenic capacities and inhibits cell proliferation by inducing apoptosis in colon cancer. Chen CH et al., 2020 Apr 16, Biochem Biophys Res CommunRead more
- Effect of RNA interference of the expression of HMGA2 on the proliferation and invasion ability of ACHN renal cell carcinoma cells. Liu Y et al., 2017 Oct, Mol Med RepRead more
- HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization. Tang C et al., 2021 Apr 29, Cell Death DisRead more
- HMGA2 promotes vasculogenic mimicry and tumor aggressiveness by upregulating Twist1 in gastric carcinoma. Sun J et al., 2017 May 22, Sci RepRead more
- Identification of HMGA2 inhibitors by AlphaScreen-based ultra-high-throughput screening assays. Su L et al., 2020 Nov 2, Sci RepRead more
- Metformin alleviates breast cancer through targeting high-mobility group AT-hook 2. Li Y et al., 2020 Mar, Thorac CancerRead more
- MiR-107 suppresses proliferation of hepatoma cells through targeting HMGA2 mRNA 3UTR. Wang Y et al., 2016 Nov 18, Biochem Biophys Res CommunRead more
- Multiple myeloma driving factor WHSC1 is a transcription target of oncogene HMGA2 that facilitates colon cancer proliferation and metastasis. Liu HH et al., 2021 Aug 27, Biochem Biophys Res CommunRead more