InVivoMAb anti-mouse CD40

Name: InVivoMAb anti-mouse CD40
SKU: BE0016-2_B56
Price: 4940 EUR
Availability: BackOrder

BE0016-2

ApplicationsOther Application

Product group Antibodies

ReactivityMouse

Overview

Supplier
Bio X Cell
Product Name
InVivoMAb anti-mouse CD40
Delivery Days Customer
7
Applications
Other Application
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
FGK4.5/FGK45
Concentration
4-11 mg/ml
Host
Rat
Isotype
IgG2a
Scientific Description
The FGK4.5 monoclonal antibody reacts with mouse CD40 also known as Bp50. CD40 is a 48 kDa type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. Agonistic CD40 monoclonal antibodies have been shown to activate APCs and promote anti-tumor T cell responses. The FGK4.5 antibody is an agonistic antibody that has been shown to activate CD40 expressing APCs. FGK4.5 can also be used to inhibit CD40/CD154 interaction in vitro and in vivo.
Reactivity
Mouse
Storage Instruction
2°C to 8°C
UNSPSC
12352203

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Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion. Hailemichael Y et al., 2013 Apr, Nat Med
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