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InVivoMAb anti-mouse CD40

Research Use Only
BE0016-2
Bio X Cell
ApplicationsOther Application
Product group Antibodies
ReactivityMouse
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Overview

  • Supplier
    Bio X Cell
  • Product Name
    InVivoMAb anti-mouse CD40
  • Delivery Days Customer
    7
  • Applications
    Other Application
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    FGK4.5/FGK45
  • Concentration
    4-11 mg/ml
  • Estimated Purity
    >95%
  • Host
    Rat
  • Isotype
    IgG2a
  • Scientific Description
    The FGK4.5 monoclonal antibody reacts with mouse CD40 also known as Bp50. CD40 is a 48 kDa type I transmembrane glycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD40 is expressed broadly on antigen-presenting cells (APCs) such as dendritic cells, B cells, macrophages, and monocytes as well as non-immune endothelial cells, basal epithelial cells, and a range of tumors. Upon binding to its ligand CD154, CD40 acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other APCs. CD40 plays roles in B cell activation, differentiation, proliferation and Ig isotype switching as well as dendritic cell maturation. Agonistic CD40 monoclonal antibodies have been shown to activate APCs and promote anti-tumor T cell responses. The FGK4.5 antibody is an agonistic antibody that has been shown to activate CD40 expressing APCs. FGK4.5 can also be used to inhibit CD40/CD154 interaction in vitro and in vivo.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • LAG3+ Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1+ Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis. Bauche D et al., 2018 Aug 21, Immunity
    Read more
  • Regulation of bifurcating B cell trajectories by mutual antagonism between transcription factors IRF4 and IRF8. Xu H et al., 2015 Dec, Nat Immunol
    Read more
  • Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine. Bartkowiak T et al., 2015 Sep 22, Proc Natl Acad Sci U S A
    Read more
  • DC-SIGN(+) Macrophages Control the Induction of Transplantation Tolerance. Conde P et al., 2015 Jun 16, Immunity
    Read more
  • Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Carmi Y et al., 2015 May 7, Nature
    Read more
  • Programmed death-1 impairs secondary effector lung CD8+ T cells during respiratory virus reinfection. Erickson JJ et al., 2014 Nov 15, J Immunol
    Read more
  • Loss of signalling via Galpha13 in germinal centre B-cell-derived lymphoma. Muppidi JR et al., 2014 Dec 11, Nature
    Read more
  • Differential kinetics of antigen dependency of CD4+ and CD8+ T cells. Rabenstein H et al., 2014 Apr 15, J Immunol
    Read more
  • Persistent antigen at vaccination sites induces tumor-specific CD8+ T cell sequestration, dysfunction and deletion. Hailemichael Y et al., 2013 Apr, Nat Med
    Read more
  • Primary oligodendrocyte death does not elicit anti-CNS immunity. Locatelli G et al., 2012 Feb 26, Nat Neurosci
    Read more

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