[KO Validated] Lamin A/C Rabbit mAb

Catalog number: A19524_50ul
Brand: ABClonal
Packing: 50 ul
Other sizes: Other sizes available
Price: On Request
Expected delivery time: 12 days
Quantity:

Product specifications for - [KO Validated] Lamin A/C Rabbit mAb

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Storage instructions: Store at -20-¦C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Scientific information: 
Scientific info: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Additional information: 
Synonyms: RabMabs; Cytoskeleton Regulation