Overview
- SupplierGeneTex
- Product NameMDM2 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.11 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Autoantibodies response to MDM2 and p53 in the immunodiagnosis of esophageal squamous cell carcinoma. Chai Y et al., 2014 Nov, Scand J ImmunolRead more
- Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus. Liu Y et al., 2015, J Immunol ResRead more
- Mdm2 Promotes Odontoblast-like Differentiation by Ubiquitinating Dlx3 and p53. Zheng H et al., 2020 Mar, J Dent ResRead more
- Mechanisms of Targeting the MDM2-p53-FOXM1 Axis in Well-Differentiated Intestinal Neuroendocrine Tumors. Briest F et al., 2018, NeuroendocrinologyRead more
- The Anti-Apoptotic Role of EBV-LMP1 in Lymphoma Cells. Zeng M et al., 2020, Cancer Manag ResRead more
- The Anti-Apoptotic Role of EBV-LMP1 in Lymphoma Cells. Zeng M et al., 2020, Cancer Manag ResRead more
- Transketolase Regulates the Metabolic Switch to Control Breast Cancer Cell Metastasis via the alpha-Ketoglutarate Signaling Pathway. Tseng CW et al., 2018 Jun 1, Cancer ResRead more