NOTCH1 antibody

Catalog number: GTX28925_100ul
Brand: GeneTex
Packing: 100 ul
Price: € 428.00
Expected delivery time: 10 days
Quantity:
GTX28925 IHC-P Image
GTX28925 IHC-P Image...
GTX28925 WB Image
GTX28925 WB Image...
GTX28925 WB Image
GTX28925 WB Image...

Product specifications for - NOTCH1 antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: ELISA; ImmunoCytoChemistry; ImmunoFluorescence; ImmunoHistoChemistry; ImmunoHistoChemistry Parrafin; Neutralisation/Blocking; Western Blot
Species: Human, Mouse, Rat
Host: Rabbit
Target: NOTCH1
Target description: notch receptor 1
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Concentration: 78 mg/ml
Storage instructions: 2-¦C to 8-¦C, -20-¦C or -80-¦C
Scientific information: 
Scientific info: Notch 1 is synthesized in the endoplasmic reticulum as an inactive form, which is proteolytically cleaved by a furin-like convertase (S1 cleavage) in the trans-golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved (S2 cleavage) by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin-dependent gamma-secretase (S3 cleavage) to release the intracellular domain (NICD) from the membrane.
Gene ID: 4851
Swiss prot ID: P46531
Additional information: 
Synonyms: GTX_citation; AOS5; AOVD1; hN1; neurogenic locus notch homolog protein 1; notch 1; Notch homolog 1, translocation-associated; TAN1; translocation-associated notch protein TAN-1
Notch 1 signaling pathway effect on implantation competency. Chu PW et al., 2011 Nov, Fertil Steril Read more
Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Cheng X et al., 2008 Oct, Development Read more
Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Nwabo Kamdje AH et al., 2012 May, Blood Cancer J Read more
Role of stromal cell-mediated Notch signaling in CLL resistance to chemotherapy. Nwabo Kamdje AH et al., 2012 May, Blood Cancer J Read more