Overview
- SupplierGeneTex
- Product NameNQO1 antibody [C2C3], C-term
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration0.87 mg/ml
- IsotypeIgG
- Scientific DescriptionThis gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This proteins enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimers disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A new copper ionophore DPMQ protects cells against ultraviolet B irradiation by inhibiting the TRPV1 channel. Huang KF et al., 2018 Dec, J Cell PhysiolRead more
- Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities. Hori Y et al., 2021 May 3, CellsRead more
- Aryl hydrocarbon receptor is a target of 17-Allylamino-17-demethoxygeldanamycin and enhances its anticancer activity in lung adenocarcinoma cells. Chen PH et al., 2013 Mar, Mol PharmacolRead more
- Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk. Cai J et al., 2018 Nov 13, Cell RepRead more
- Baicalein Decreases Hydrogen Peroxide-Induced Damage to NG108-15 Cells via Upregulation of Nrf2. Yeh CH et al., 2015 Aug, J Cell PhysiolRead more
- Cytoplasmic localization of Nrf2 promotes colorectal cancer with more aggressive tumors via upregulation of PSMD4. Lin PL et al., 2016 Jun, Free Radic Biol MedRead more
- Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy. Lin DS et al., 2020 May 1, CellsRead more
- Lce1 Family Members Are Nrf2-Target Genes that Are Induced to Compensate for the Loss of Loricrin. Ishitsuka Y et al., 2016 Aug, J Invest DermatolRead more
- M1 Muscarinic Receptor Deficiency Attenuates Azoxymethane-Induced Chronic Liver Injury in Mice. Rachakonda V et al., 2015 Sep 16, Sci RepRead more
- Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Shin D et al., 2018 Dec, Free Radic Biol MedRead more