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ProductsBack/PD-L1 antibody

PD-L1 antibody

Research Use Only
GTX104763
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
DownloadDatasheet
Product group Antibodies
ReactivityHuman
TargetCD274
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Overview

  • Supplier
    GeneTex
  • Product Name
    PD-L1 antibody
  • Delivery Days Customer
    9
  • Antibody Specificity
    This antibody is specific for human PDL1 protein, and it does not cross react with human PDL2 protein.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.97 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID29126
  • Target name
    CD274
  • Target description
    CD274 molecule
  • Target synonyms
    B7 homolog 1; B7-H; B7H1; CD274 antigen; hPD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; programmed cell death 1 ligand 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Semaphorin 4C promotes motility and immunosuppressive activity of cancer cells via CRMP3 and PD-L1. Hung YH et al., 2022, Am J Cancer Res
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  • Programme death ligand 1 expressions as a surrogate for determining immunotherapy in cervical carcinoma patients. Omenai SA et al., 2022, PLoS One
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  • miR-4759 suppresses breast cancer through immune checkpoint blockade. Lin YZ et al., 2022, Comput Struct Biotechnol J
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  • Expression of programmed cell death ligand-1 protein in germinal center B-cell-like and non-germinal center B-cell-like subtypes of diffuse large B-cell lymphoma. Asrini R et al., 2022 Feb, Mol Clin Oncol
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  • Systematic insight into the active constituents and mechanism of Guiqi Baizhu for the treatment of gastric cancer. Li L et al., 2021 May, Cancer Sci
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  • The PD-L1 metabolic interactome intersects with choline metabolism and inflammation. Pacheco-Torres J et al., 2021 Feb 19, Cancer Metab
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  • PD-L1 as a prognostic biomarker in surgically resectable non-small cell lung cancer: a meta-analysis. Tuminello S et al., 2020 Aug, Transl Lung Cancer Res
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  • The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Chou CW et al., 2020, Am J Cancer Res
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  • NDAT Targets PI3K-Mediated PD-L1 Upregulation to Reduce Proliferation in Gefitinib-Resistant Colorectal Cancer. Huang TY et al., 2020 Aug 3, Cells
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  • Differential Expression and Clinicopathological Significance of HER2, Indoleamine 2,3-Dioxygenase and PD-L1 in Urothelial Carcinoma of the Bladder. Kim D et al., 2020 Apr 27, J Clin Med
    Read more