Presenilin 1 Polyclonal Antibody

Catalog number: GRP183
Brand: German Research Products
Packing: 100 ul
Price: € 394.00
Expected delivery time: 14 days
Quantity:

Product specifications for - Presenilin 1 Polyclonal Antibody

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Application: Western Blot, IHC-P
Species: Human, Mouse, Rat
Host: Rabbit
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Properties: 
  Research Use Only
UNSPSC: 12352203
Storage instructions: Store at -20-¦C for 12 months.
Scientific information: 
Scientific info: Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.