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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
Presenilin 1 Polyclonal Antibody
Catalog number:
GRP183
Brand:
German Research Products
Packing:
100 ul
Price:
€ 414.00
Expected delivery time:
14 days
Quantity:
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General
Product specifications for - Presenilin 1 Polyclonal Antibody
Overview:
Product group:
Antibodies
Category:
Primary Antibodies
Application:
Western Blot, IHC-P
Species:
Human, Mouse, Rat
Host:
Rabbit
Clonality:
Polyclonal
Conjugation:
Unconjugated
Isotype:
IgG
Properties:
Research Use Only
UNSPSC:
12352203
Storage instructions:
Store at -20-¦C for 12 months.
Scientific information:
Scientific info:
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Additional information:
Synonyms:
GRP183; German Research Products