ROCK1 Rabbit mAb

Catalog number: A11158_50ul
Brand: ABClonal
Packing: 50 ul
Other sizes: Other sizes available
Price: € 259.00
Expected delivery time: 12 days
Quantity:

Product specifications for - ROCK1 Rabbit mAb

Overview: 
Product group: Antibodies
Category: Primary Antibodies
Properties: 
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352203
Storage instructions: Store at -20-¦C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Scientific information: 
Scientific info: This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.
Additional information: 
Synonyms: RabMabs; Cytoskeleton Regulation