Overview
- SupplierGeneTex
- Product NameTDP43 antibody
- Delivery Days Customer9
- CertificationResearch Use Only
- Concentration1.18 mg/ml
- IsotypeIgG
- Scientific DescriptionHIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq]
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- Co-regulation of mRNA translation by TDP-43 and Fragile X Syndrome protein FMRP. Majumder P et al., 2016 Nov, Acta NeuropatholRead more
- Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. Huang CC et al., 2014 Jul 15, J Cell SciRead more
- Resources for the Comprehensive Discovery of Functional RNA Elements. Sundararaman B et al., 2016 Mar 17, Mol CellRead more
- TDP-43 Regulates Coupled Dendritic mRNA Transport-Translation Processes in Co-operation with FMRP and Staufen1. Chu JF et al., 2019 Dec 3, Cell RepRead more
- Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons. Wu LS et al., 2019 Mar 29, Acta Neuropathol CommunRead more