GTX627420 WB Image
GTX627420 WB Image
TET1 antibody [GT1462] - KO/KD, Orthogonal, Overexpression Validated
GTX627420
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
Overview
- SupplierGeneTex
- Product NameTET1 antibody [GT1462] - KO/KD, Orthogonal, Overexpression Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDGT1462
- Concentration1 mg/ml
- HostMouse
- IsotypeIgG
- Scientific DescriptionDioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- TET1 Knockdown Inhibits Porphyromonas gingivalis LPS/IFN-gamma-Induced M1 Macrophage Polarization through the NF-kappaB Pathway in THP-1 Cells. Huang Y et al., 2019 Apr 24, Int J Mol SciRead more
- A novel cancer-germline transcript carrying pro-metastatic miR-105 and TET-targeting miR-767 induced by DNA hypomethylation in tumors. Loriot A et al., 2014 Aug, EpigeneticsRead more
- Comprehensive nucleosome interactome screen establishes fundamental principles of nucleosome binding. Skrajna A et al., 2020 Sep 25, Nucleic Acids ResRead more
- DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription. Feng W et al., 2020 Jun 15, Mol Cell BiolRead more
- DNA Demethylation by DNMT3A and DNMT3B in vitro and of Methylated Episomal DNA in Transiently Transfected Cells. Chatterjee B et al., 2018 Nov, Biochim Biophys Acta Gene Regul MechRead more
- Epigenetic underpinnings of freeze avoidance in the goldenrod gall moth, Epiblema scudderiana. Williamson SM et al., 2021 Oct, J Insect PhysiolRead more
- Expression features of DNA methylcytosine dioxygenase ten-eleven translocation 1 in human dental pulp cells. Li Q et al., 2014 Nov, J EndodRead more
- FAM20C could be targeted by TET1 to promote odontoblastic differentiation potential of human dental pulp cells. Li Q et al., 2018 Apr, Cell ProlifRead more
- FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function. Yang YA et al., 2016 Sep 30, Nucleic Acids ResRead more
- Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes. Peng C et al., 2021 Feb, J Cell PhysiolRead more