GTX125888 WB Image
TET1 antibody [N1], N-term - KO/KD Validated
GTX125888
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
Overview
- SupplierGeneTex
- Product NameTET1 antibody [N1], N-term - KO/KD Validated
- Delivery Days Customer10
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- HostRabbit
- IsotypeIgG
- Scientific DescriptionDioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.
- ReactivityHuman, Mouse
- Storage Instruction2°C to 8°C,-20°C
- UNSPSC12352203
References
- A Critical Role of TET1/2 Proteins in Cell-Cycle Progression of Trophoblast Stem Cells. Chrysanthou S et al., 2018 Apr 10, Stem Cell ReportsRead more
- Coordination of germ layer lineage choice by TET1 during primed pluripotency. Luo X et al., 2020 Apr 1, Genes DevRead more
- Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte. Hill PWS et al., 2018 Mar 15, NatureRead more
- Individual retrotransposon integrants are differentially controlled by KZFP/KAP1-dependent histone methylation, DNA methylation and TET-mediated hydroxymethylation in naive embryonic stem cells. Coluccio A et al., 2018 Feb 26, Epigenetics ChromatinRead more
- Metformin sensitizes endometrial cancer cells to chemotherapy through IDH1-induced Nrf2 expression via an epigenetic mechanism. Bai M et al., 2018 Oct, OncogeneRead more
- miR-29 regulates Tet1 expression and contributes to early differentiation of mouse ESCs. Cui Y et al., 2016 Oct 4, OncotargetRead more
- Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming. Bartoccetti M et al., 2020 Feb 18, Cell RepRead more
- Reprogramming competence of OCT factors is determined by transactivation domains. Kim KP et al., 2020 Sep, Sci AdvRead more
- Reprogramming competence of OCT factors is determined by transactivation domains. Kim KP et al., 2020 Sep, Sci AdvRead more
- Simultaneous deletion of the methylcytosine oxidases Tet1 and Tet3 increases transcriptome variability in early embryogenesis. Kang J et al., 2015 Aug 4, Proc Natl Acad Sci U S ARead more